Dynamic modeling and optimal control of cystic echinococcosis

Abstract Background Cystic echinococcosis is one of the most severe helminth zoonosis with a drastic impact on human health and livestock industry. Investigating optimal control strategy assessing crucial factors are essential for developing countermeasures to mitigate this disease. Methods Two compartment models were formulated study dynamics cystic transmission, evaluate effectiveness various measures, find strategy. Sensitive analyses conducted by obtaining PRCCs contour plot was used effect key parameters basic reproduction number. Based forward–backward sweep method, numerical simulations employed investigate effects transmission obtain Results The food resources stray dog invalid sheep vaccination rate, which always neglected, significant echinococcosis. Numerical suggest that, implementation can significantly reduce infections. Improving cost education domestic deworming could not decrease Conclusions Our showed that only long-term use measures eliminate Meanwhile, during intervention, dogs disposing should be emphasized ahead minimize cost. Simultaneously reducing other wild intermediate hosts strengthening as well would effective.